Pesquisa | Secretaria de Estado da Saúde

1.

Atlas of the aging mouse brain reveals white matter as vulnerable foci.

Hahn, Oliver; Foltz, Aulden G; Atkins, Micaiah; Kedir, Blen; Moran-Losada, Patricia; Guldner, Ian H; Munson, Christy; Kern, Fabian; Pálovics, Róbert; Lu, Nannan; Zhang, Hui; Kaur, Achint; Hull, Jacob; Huguenard, John R; Grönke, Sebastian; Lehallier, Benoit; Partridge, Linda; Keller, Andreas; Wyss-Coray, Tony.

Cell ; 186(19): 4117-4133.e22, 2023 09 14.

Artigo Inglês | MEDLINE | ID: mdl-37591239

2.

ß2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function.

Gao, Yue; Hong, Yujuan; Huang, Lihong; Zheng, Shuang; Zhang, Haibin; Wang, Shihua; Yao, Yi; Zhao, Yini; Zhu, Lin; Xu, Qiang; Chai, Xuhui; Zeng, Yuanyuan; Zeng, Yuzhe; Zheng, Liangkai; Zhou, Yulin; Luo, Hong; Zhang, Xian; Zhang, Hongfeng; Zhou, Ying; Fu, Guo; Sun, Hao; Huang, Timothy Y; Zheng, Qiuyang; Xu, Huaxi; Wang, Xin.

Cell ; 186(5): 1026-1038.e20, 2023 03 02.

Artigo Inglês | MEDLINE | ID: mdl-36868208

3.

Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology.

Mathys, Hansruedi; Peng, Zhuyu; Boix, Carles A; Victor, Matheus B; Leary, Noelle; Babu, Sudhagar; Abdelhady, Ghada; Jiang, Xueqiao; Ng, Ayesha P; Ghafari, Kimia; Kunisky, Alexander K; Mantero, Julio; Galani, Kyriaki; Lohia, Vanshika N; Fortier, Gabrielle E; Lotfi, Yasmine; Ivey, Jason; Brown, Hannah P; Patel, Pratham R; Chakraborty, Nehal; Beaudway, Jacob I; Imhoff, Elizabeth J; Keeler, Cameron F; McChesney, Maren M; Patel, Haishal H; Patel, Sahil P; Thai, Megan T; Bennett, David A; Kellis, Manolis; Tsai, Li-Huei.

Cell ; 186(20): 4365-4385.e27, 2023 09 28.

Artigo Inglês | MEDLINE | ID: mdl-37774677

4.

Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment.

Piehl, Natalie; van Olst, Lynn; Ramakrishnan, Abhirami; Teregulova, Victoria; Simonton, Brooke; Zhang, Ziyang; Tapp, Emma; Channappa, Divya; Oh, Hamilton; Losada, Patricia M; Rutledge, Jarod; Trelle, Alexandra N; Mormino, Elizabeth C; Elahi, Fanny; Galasko, Douglas R; Henderson, Victor W; Wagner, Anthony D; Wyss-Coray, Tony; Gate, David.

Cell ; 185(26): 5028-5039.e13, 2022 12 22.

Artigo Inglês | MEDLINE | ID: mdl-36516855

5.

COVID fog demystified.

Kao, Jennifer; Frankland, Paul W.

Cell ; 185(14): 2391-2393, 2022 07 07.

Artigo Inglês | MEDLINE | ID: mdl-35768007

6.

Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner.

Willis, Emily F; MacDonald, Kelli P A; Nguyen, Quan H; Garrido, Adahir Labrador; Gillespie, Ellen R; Harley, Samuel B R; Bartlett, Perry F; Schroder, Wayne A; Yates, Abi G; Anthony, Daniel C; Rose-John, Stefan; Ruitenberg, Marc J; Vukovic, Jana.

Cell ; 180(5): 833-846.e16, 2020 03 05.

Artigo Inglês | MEDLINE | ID: mdl-32142677

7.

Clearing the Fog surrounding Chemobrain.

Gutmann, David H.

Cell ; 176(1-2): 2-4, 2019 01 10.

Artigo Inglês | MEDLINE | ID: mdl-30633904

8.

When Time Matters: An Adolescent Intervention to Prevent Adult Brain Dysfunction.

Canetta, Sarah; Kellendonk, Christoph.

Cell ; 178(6): 1282-1284, 2019 09 05.

Artigo Inglês | MEDLINE | ID: mdl-31474365

9.

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment.

Gibson, Erin M; Nagaraja, Surya; Ocampo, Alfonso; Tam, Lydia T; Wood, Lauren S; Pallegar, Praveen N; Greene, Jacob J; Geraghty, Anna C; Goldstein, Andrea K; Ni, Lijun; Woo, Pamelyn J; Barres, Ben A; Liddelow, Shane; Vogel, Hannes; Monje, Michelle.

Cell ; 176(1-2): 43-55.e13, 2019 01 10.

Artigo Inglês | MEDLINE | ID: mdl-30528430

10.

Long-Lasting Rescue of Network and Cognitive Dysfunction in a Genetic Schizophrenia Model.

Mukherjee, Arghya; Carvalho, Fernando; Eliez, Stephan; Caroni, Pico.

Cell ; 178(6): 1387-1402.e14, 2019 09 05.

Artigo Inglês | MEDLINE | ID: mdl-31474363

11.

Self-sustaining inflammatory cycle causes memory impairment in neuropsychiatric lupus.

Nat Immunol ; 25(4): 596-597, 2024 Apr.

Artigo Inglês | MEDLINE | ID: mdl-38519649

12.

Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1.

Garber, Charise; Vasek, Michael J; Vollmer, Lauren L; Sun, Tony; Jiang, Xiaoping; Klein, Robyn S.

Nat Immunol ; 19(2): 151-161, 2018 02.

Artigo Inglês | MEDLINE | ID: mdl-29292385

13.

Formation of memory assemblies through the DNA-sensing TLR9 pathway.

Jovasevic, Vladimir; Wood, Elizabeth M; Cicvaric, Ana; Zhang, Hui; Petrovic, Zorica; Carboncino, Anna; Parker, Kendra K; Bassett, Thomas E; Moltesen, Maria; Yamawaki, Naoki; Login, Hande; Kalucka, Joanna; Sananbenesi, Farahnaz; Zhang, Xusheng; Fischer, Andre; Radulovic, Jelena.

Nature ; 628(8006): 145-153, 2024 Apr.

Artigo Inglês | MEDLINE | ID: mdl-38538785

14.

cGAS-STING drives ageing-related inflammation and neurodegeneration.

Gulen, Muhammet F; Samson, Natasha; Keller, Alexander; Schwabenland, Marius; Liu, Chong; Glück, Selene; Thacker, Vivek V; Favre, Lucie; Mangeat, Bastien; Kroese, Lona J; Krimpenfort, Paul; Prinz, Marco; Ablasser, Andrea.

Nature ; 620(7973): 374-380, 2023 Aug.

Artigo Inglês | MEDLINE | ID: mdl-37532932

15.

Platelet factors attenuate inflammation and rescue cognition in ageing.

Schroer, Adam B; Ventura, Patrick B; Sucharov, Juliana; Misra, Rhea; Chui, M K Kirsten; Bieri, Gregor; Horowitz, Alana M; Smith, Lucas K; Encabo, Katriel; Tenggara, Imelda; Couthouis, Julien; Gross, Joshua D; Chan, June M; Luke, Anthony; Villeda, Saul A.

Nature ; 620(7976): 1071-1079, 2023 Aug.

Artigo Inglês | MEDLINE | ID: mdl-37587343

16.

Organ aging signatures in the plasma proteome track health and disease.

Oh, Hamilton Se-Hwee; Rutledge, Jarod; Nachun, Daniel; Pálovics, Róbert; Abiose, Olamide; Moran-Losada, Patricia; Channappa, Divya; Urey, Deniz Yagmur; Kim, Kate; Sung, Yun Ju; Wang, Lihua; Timsina, Jigyasha; Western, Dan; Liu, Menghan; Kohlfeld, Pat; Budde, John; Wilson, Edward N; Guen, Yann; Maurer, Taylor M; Haney, Michael; Yang, Andrew C; He, Zihuai; Greicius, Michael D; Andreasson, Katrin I; Sathyan, Sanish; Weiss, Erica F; Milman, Sofiya; Barzilai, Nir; Cruchaga, Carlos; Wagner, Anthony D; Mormino, Elizabeth; Lehallier, Benoit; Henderson, Victor W; Longo, Frank M; Montgomery, Stephen B; Wyss-Coray, Tony.

Nature ; 624(7990): 164-172, 2023 Dec.

Artigo Inglês | MEDLINE | ID: mdl-38057571

17.

Impairments to Consolidation, Reconsolidation, and Long-Term Memory Maintenance Lead to Memory Erasure.

Haubrich, Josué; Bernabo, Matteo; Baker, Andrew G; Nader, Karim.

Annu Rev Neurosci ; 43: 297-314, 2020 07 08.

Artigo Inglês | MEDLINE | ID: mdl-32097575

18.

Medin co-aggregates with vascular amyloid-ß in Alzheimer's disease.

Wagner, Jessica; Degenhardt, Karoline; Veit, Marleen; Louros, Nikolaos; Konstantoulea, Katerina; Skodras, Angelos; Wild, Katleen; Liu, Ping; Obermüller, Ulrike; Bansal, Vikas; Dalmia, Anupriya; Häsler, Lisa M; Lambert, Marius; De Vleeschouwer, Matthias; Davies, Hannah A; Madine, Jillian; Kronenberg-Versteeg, Deborah; Feederle, Regina; Del Turco, Domenico; Nilsson, K Peter R; Lashley, Tammaryn; Deller, Thomas; Gearing, Marla; Walker, Lary C; Heutink, Peter; Rousseau, Frederic; Schymkowitz, Joost; Jucker, Mathias; Neher, Jonas J.

Nature ; 612(7938): 123-131, 2022 12.

Artigo Inglês | MEDLINE | ID: mdl-36385530

19.

Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.

Gonatopoulos-Pournatzis, Thomas; Niibori, Rieko; Salter, Eric W; Weatheritt, Robert J; Tsang, Brian; Farhangmehr, Shaghayegh; Liang, Xinyi; Braunschweig, Ulrich; Roth, Jonathan; Zhang, Shen; Henderson, Tyler; Sharma, Eesha; Quesnel-Vallières, Mathieu; Permanyer, Jon; Maier, Stefan; Georgiou, John; Irimia, Manuel; Sonenberg, Nahum; Forman-Kay, Julie D; Gingras, Anne-Claude; Collingridge, Graham L; Woodin, Melanie A; Cordes, Sabine P; Blencowe, Benjamin J.

Mol Cell ; 77(6): 1176-1192.e16, 2020 03 19.

Artigo Inglês | MEDLINE | ID: mdl-31999954

20.

Biomarker Changes during 20 Years Preceding Alzheimer's Disease.

Jia, Jianping; Ning, Yuye; Chen, Meilin; Wang, Shuheng; Yang, Hao; Li, Fangyu; Ding, Jiayi; Li, Yan; Zhao, Bote; Lyu, Jihui; Yang, Shanshan; Yan, Xin; Wang, Yue; Qin, Wei; Wang, Qi; Li, Ying; Zhang, Jintao; Liang, Furu; Liao, Zhengluan; Wang, Shan.

N Engl J Med ; 390(8): 712-722, 2024 Feb 22.

Artigo Inglês | MEDLINE | ID: mdl-38381674

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